In haploidentical stem cell transplantations (haplo-SCT), nearly all patients have more than one donor. A key issue in\nthe haplo-SCT setting is the search for the best donor, because donor selection can significantly impact the\nincidences of acute and chronic graft-versus-host disease, transplant-related mortality, and relapse, in addition to\noverall survival. In this review, we focused on factors associated with transplant outcomes following unmanipulated\nhaplo-SCT with anti-thymocyte globulin (ATG) or after T-cell-replete haplo-SCT with post-transplantation\ncyclophosphamide (PT/Cy). We summarized the effects of the primary factors, including donor-specific antibodies\nagainst human leukocyte antigens (HLA); donor age and gender; killer immunoglobulin-like receptor-ligand\nmismatches; and non-inherited maternal antigen mismatches. We also offered some expert recommendations and\nproposed an algorithm for selecting donors for unmanipulated haplo-SCT with ATG and for T-cell-replete haplo-SCT\nwith PT/Cy.
Loading....